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Regenerative Medicine Statement concerning Stem Cell therapy:

These are non-surgical treatments that are designed to assist the body’s natural healing by activating and increasing the local cells that are responsible for repairing damaged tissue. Regenerative medicine is a term often used interchangeably with tissue engineering, repairing, and regrowing, and aims to orchestrate body regeneration by specifically controlling and signaling the body’s own biological environment. Stem cells (MSC) are cells of the body (somatic cells) which can divide and become differentiated. All the different kinds of cells in the human body develop from stem cells. When an organism grows, stem cells specialize, and take on specific functions. For instance, mature tissues like skin, muscle, blood, bone, liver, and nerves, all have different types of cells and start as stem cells. MSC Wharton’s Jelly is a specialized umbilical cord tissue whose primary function is to physically support and serve as a barrier or conduit, connect, cover, and/or cushion different tissues of the body.

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Minimal Manipulation

1)For structural tissue, processing does not alter the original relevant characteristics of the tissue relating to the tissue’s utility for reconstruction, repair, or replacement.EXAMPLE: Will NOT make muscles grow (HGH), but repair the damaged injured muscle tissue  2) For cells or nonstructural tissues, processing does not alter the relevant biological characteristics of cells or tissues only assist and signal healing to the necessary cells and tissue. . The International Society for Cellular Therapy defines mesenchymal stem cells (MSC) In 2017, then FDA Commissioner Scott Gottlieb, M.D. stated that “we’re at the beginning of a paradigm change in medicine with the promise of being able to facilitate regeneration of parts of the human body, where cells and tissues can be engineered to grow healthy, functional organs to replace diseased ones; new genes can be introduced into the body to combat disease; and adult stem cells can generate replacements for cells that are lost to injury or disease. This is the practical promise of modern applications of regenerative medicine” [20]. MSC cells are optimal for regenerative therapy usage due to their immunoregulatory properties; paracrine and autocrine functions that generate growth factors (GF); and their ability to differentiate into various cell lineages including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (smooth muscle cells), adipocytes (fat cells), fibroblasts, and hematopoietic stroma according to the requirement of specific biomedical applications [21,22]. In vivo, MSC actively migrates to cartilage ischemia and damaged tissue sites within the articular microenvironment; expresses enzymes; and secrete numerous nutritional factors including GF, cytokines, and chemokines which repair cartilage tissue and suppress the secretion of inflammatory factors [23].

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What are inside Exosomes?

They are tiny vesicles that are smaller than cells that carry the vital nutrients and GF, and proteins to the various places we’re trying to reach and heal. No DNA is present in Exosomes. Growth factors are critical signaling molecules that instruct cells during development, and one may achieve tissue regeneration in the adult by enabling control over growth factor delivery.Tissue-regeneration strategies are often broken down into three categories: (i) Direct injection of bolus cells into the tissue of interest or the systematic circulation (IV) , (ii) implantation of cells after they have been combined to form a three-dimensional tissue structure, often within a bioreactor, and (iii) scaffold-based delivery of signaling molecules such as low-molecular-weight drugs, proteins, and oligonucleotides that stimulate cell migration, growth, and differentiation. Categories of mitogens (stimulate cell division), growth factors (originally identified by their proliferation-inducing effects, but have multiple functions), and morphogens (control generation of tissue form). Precise control over the signaling of these factors in a local area may potentially allow control over a regenerative process. As is typical in this field, the term growth factor will be broadly used for proteins, which affects cell migration, proliferation, and cellular differentiation. There are thousands of different types of GF in the human body! Stem /Exosomes Vs. PRP injections- Instant inflammatory relief and signaling the body’s natural healing mechanisms for a faster recovery. Whereas PRP forces inflammation causing more discomfort before relief if any due to the Quality of the PRP used. Regeneration in adults often represents a recapitulation of developmental processes and strives to maintain and/or restore tissue integrity and functionality.

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